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The p53 tumour suppressor gene

Nature volume 351, pages 453–456 (1991) Cite this article

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Abstract

The cell cycle is composed of a series of steps which can be negatively or postively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.

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Authors and Affiliations

  1. Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, 08544-1014, USA

    Arnold J. Levine, Jamil Momand & Cathy A. Finlay

Authors
  1. Arnold J. Levine
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  2. Jamil Momand
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  3. Cathy A. Finlay
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Levine, A., Momand, J. & Finlay, C. The p53 tumour suppressor gene. Nature 351, 453–456 (1991). https://doi.org/10.1038/351453a0

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