We independently evaluate all of our recommendations. If you click on links we provide, we may receive compensation. The 15 Best Niacinamide Serums for Brightening and Smoothing Skin, Tested by InStyle We spent 10,000+ hours of testing to find the most worthy serums. By Emily Orofino Emily Orofino Emily Orofino has over a decade of experience working in beauty. You can find her work on sites such as Harper’s Bazaar, Byrdie, Editorialist, POPSUGAR, & RealSelf. She has also lent her expertise to marketing departments & product development teams of some of the industry’s most prestigious brands. InStyle's editorial guidelines and Emma Greene Emma Greene Emma specializes in fashion and beauty reviews. She began her career at InStyle in 2025 and has a wealth of styling experience for fashion magazines, retail stores, and beyond. She's passionate about both high-end and attainable fashion and is an expert minimalist. InStyle's editorial guidelines Updated on April 8, 2026 @ 11:37AM In This Article View All In This Article Top Picks Reviews Our Testing Process What to Keep in Mind Your Questions, Answered Why Shop With Us Credit: InStyle Sunday Riley B3 Nice 10% Niacinamide Serum is our favorite because its formula absorbs easily and contains antioxidants that brighten and clear skin while preventing dark spots from forming. As we evaluated each serum’s consistency, absorption, and efficacy, we also noted how well it layered with other products. Niacinamide is a prevalent ingredient in many products, so exercise caution when adding it to your existing routine and consider sticking to lower concentrations until you know how your skin reacts to the serum. Sure, there’s merit to a maximalist, 15-step skin care routine, but we’re willing to wager that most people want to get the job done as efficiently as possible. So if you’re trying to get the best skin you can while putting in practically zero effort, a niacinamide serum should be in the mix. Niacinamide is a form of vitamin B that “has been shown to reverse and prevent signs of aging, brighten and smooth skin, reduce hyperpigmentation, decrease the appearance of pores, and hydrate and support the skin barrier,” says Blair Murphy-Rose, M.D., a board-certified dermatologist and founder of Skincare Junkie. Because this ingredient can do so much, it's no surprise that niacinamide is one of the most popular skin care ingredients today. But there’s no need to comb through all the serums available, because we’ve already done it for you. We devoted almost 10,000 hours (no kidding!) to testing 29 unique niacinamide serums over eight weeks, judging them on their consistency, absorption, efficacy, and overall results. From there, we narrowed the list to the 15 best niacinamide serums below. Top Picks Best Niacinamide Serum Overall: Sunday Riley B3 Nice 10% Niacinamide Serum at Amazon $65 Jump to Review Best Niacinamide Serum for Aging Skin: SkinCeuticals Metacell Renewal B3 Face Cream with Niacinamide at Dermstore $130 Jump to Review Best Budget Niacinamide Serum: The Ordinary Niacinamide 10% + Zinc 1% at Amazon $6 Jump to Review Best Korean Niacinamide Serum: SALE Beauty of Joseon Glow Serum at Amazon $17 $13 Jump to Review Best Niacinamide Serum for Acne-Prone Skin: SALE Cosrx The Niacinamide 15 Serum at Amazon $25 $20 Jump to Review Best Niacinamide Serum for Pores: Paula's Choice Clinical Niacinamide 20% Treatment at Amazon $55 Jump to Review Best Niacinamide Serum for Dark Spots: PCA SKIN Vitamin B3 Brightening Serum at Amazon $130 Jump to Review Best Niacinamide Serum for Dry Skin: Glow Recipe Watermelon Glow Niacinamide Dew Drops at Amazon $36 Jump to Review Best Niacinamide Serum for Oily Skin: Glossier Super Pure Serum with Niacinamide + Zinc at Amazon $45 Jump to Review Best Niacinamide and Hyaluronic Acid Serum: Westman Atelier Skin Activator Serum with Hyaluronic Acid + Niacinamide at Amazon $189 Jump to Review Best Niacinamide Serum Overall Sunday Riley B3 Nice 10% Niacinamide Serum Credit: Ulta $65 $62 at Amazon $65 at Nordstrom $65 at Dermstore Why We Love It: This is the first niacinamide serum our tester Natalie had ever tried, and it completely blew the serums she’d previously used out of the water. Though the texture of this product is very fluid, it spreads and absorbs easily, with a little bit going a long way. It left her skin dewy, and, though she's prone to blemishes, it helped to brighten and clear her skin throughout the testing period. Who It's For: In addition to niacinamide, our best niacinamide serum contains potent antioxidants, which defend skin from dark-spot-forming free radicals, and a lab-created ingredient, Brightenyl, which works with the skin’s microbiome to prevent the development of dark spots, reduce redness, and shrink pore size. It's an excellent choice for those facing acne and hyperpigmentation, or who want brighter, glowier skin. Worth Noting: This comprehensive serum is formulated for all skin types, but the high concentration of niacinamide could irritate very sensitive skin. Key Ingredients: Trans-resveratrol, epigallocatechin gallatyl glucoside, Brightenyl | Fragrance-Free: Yes | Application: Once or twice daily | Size: 1 oz Natalie, tester with combination skin: “My skin definitely improved during the testing period. My skin was much clearer, softer, and brighter...and the product prevented me from breaking out.” Best Niacinamide Serum for Aging Skin SkinCeuticals Metacell Renewal B3 Face Cream with Niacinamide Credit: SkinCeuticals $130 at Dermstore $130 at Bluemercury.com $130 at Skinceuticals.com Why We Love It: Melasma is notoriously challenging to treat, especially on aging skin, but this potent formula from SkinCeuticals was up to the challenge. This overall best niacinamide serum brightened some of tester Hilary’s darker patches of melasma, smoothed her fine lines, and made her skin look brighter, younger, and healthier overall. The gel serum also gave the skin a matte finish that looked good when worn solo or under makeup. Who It's For: Beyond the fact that it’s a nice choice for those looking to address discoloration (including melasma!) and uneven skin texture, SkinCeuticals is a brand beloved by dermatologists, so give this one a shot if you want to earn a gold star at your next appointment. Like all the products from the company, this serum is formulated with well-studied, hardworking ingredients, including three firming peptides and five percent niacinamide, and has been clinically tested. Worth Noting: This product leaves a matte finish on the skin, so look elsewhere if you aspire for a dewy complexion. Key Ingredients: Peptide blend, glycerin, algae extract|Fragrance-Free: Yes|Application: Morning and night|Size: 1.7 oz Credit: InStyle Credit: InStyle Hilary, tester with dry skin and melasma: “I noticed more change to my skin texture and fine lines using this than I have with other products…my skin brightened, and I noticed some fading of the darker melasma spots on my skin. Day to day, I didn't notice much difference, but with consistent use, there is a payoff in vibrancy, texture, and discoloration.” Best Budget Niacinamide Serum The Ordinary Niacinamide 10% + Zinc 1% Credit: Sephora $6 at Amazon $6 at Nordstrom $6 at Target Why We Love It: Don’t be fooled by the brief ingredient list or the low price point of this product. The serum is incredibly effective, noticeably taming excess oil, fading dark spots, and subduing tester Hannah's stubborn breakouts in just three weeks. After eight weeks of twice-daily application, they say their results had only gotten better, and they still weren't even halfway through the bottle; a little bit goes that far. Who It's For: It’s not easy to find a serum that’s more affordable than a cup of coffee, but this one is—and it’s really effective, too. It’s ideal for those with oily and acne-prone skin due to the blend of the serum’s star ingredients, a high concentration of niacinamide and zinc, which Dr. Murphy-Rose says is known to fight blemishes; it kills breakout-causing bacteria while reducing oil production and inflammation. However, our tester has dry skin, and still loves (and plans to repurchase) this product. Worth Noting: Hannah says the product dries tight on the face, but the feeling goes away once moisturizer is applied on top. Key Ingredients: Niacinamide, zinc | Fragrance-Free: Yes | Application: Morning and night | Size: 1 oz Hannah, tester with dry, acne-prone skin: “There’s a reason for the hype. I’ve tried other niacinamide serums before, but this is one I plan to repurchase.” Best Korean Niacinamide Serum Beauty of Joseon Glow Serum Credit: Amazon $17 $13 at Amazon $17 $14 at Yesstyle.com $17 at Beautyofjoseon.com Why We Love It: This formula absorbed very rapidly without leaving residue, instantly boosting hydration levels and leaving our tester Juliet’s skin looking moisturized, soft, and poreless. She found it soothing, and despite her highly sensitive skin, never experienced irritation. She also says it layered well with the other products in her rotation, which include hyaluronic acid and vitamin C serums, retinol, moisturizer, and sunscreen. Who It's For: This is a nice option for those with sensitive skin because of the high concentration (60 percent!) of propolis extract, a resin-like substance made by bees that has powerful anti-inflammatory and antibacterial properties, and beautifully supports the soothing benefits of niacinamide. It also contains hydrating sodium hyaluronate and glycerin, and brightening turmeric extract. The formula is quite clean, so those who are picky about the ingredients in their products will appreciate this, too. Worth Noting: This formula initially feels sticky on the skin but absorbs quickly. Key Ingredients: Propolis extract, sodium hyaluronate, turmeric extract | Fragrance-Free: Yes | Application: Once or twice daily | Size: 1 oz Juliet, tester with dry, sensitive skin: “I really like the product overall…I felt like my skin was bouncier after consistent use…there was no smell whatsoever, which was really nice, and the product in no way irritated my skin. I saw results mostly overnight when I woke up in the morning." Best Niacinamide Serum for Acne-Prone Skin Cosrx The Niacinamide 15 Serum Credit: COSRX $25 $20 at Amazon $25 at Nordstrom $25 at Ulta Why We Love It: Our tester Drea was wildly impressed by her results after using this serum for eight weeks. She had significantly fewer breakouts while using this product, and her dark spots seemed to disappear. Most noticeably, it erased acne scars that she’d had for years and thought she’d need medical intervention to address. Who It's For: Just a dime-sized drop of this niacinamide serum each morning and night transforms acne-prone (and formerly acne-prone) skin. Packing 15 percent niacinamide, soothing allantoin, and N-acetyl glucosamine (NAG), a chemical found in the body that’s been proven to be a powerful skin brightener, it yields more even, glowing skin, with consistent use, even where acne scars once were. Worth Noting: Niacinamide, allantoin, and NAG are well-tolerated and comforting to the skin, so this product is worth a try by those who struggle with breakouts and have very sensitive skin. Key Ingredients: N-Acetylglucosamine, zinc, allantoin | Fragrance-Free: Yes | Application: Once or twice daily | Size: 0.67 oz Drea, tester with large pores and acne scars: “I can't think of anything that I would change about this product…It is easy to use and has great results…This took care of some acne scarring that I really thought needed additional attention. My skin seemed to even out and looks healthy.” Best Niacinamide Serum for Pores Paula's Choice Clinical Niacinamide 20% Treatment Credit: Amazon $55 at Amazon $55 at Sephora $55 at Dermstore Why We Love It: Our tester saw a true difference in her skin’s plumpness, clarity, texture, and tone after adding this serum to her routine. It made her skin extremely clear—which isn’t typical for her—and her pores appeared much, much smaller. Mollie combined the niacinamide serum with tretinoin, which she says transformed her regimen for the better. She says it had a "clinical-grade" feel to it, melting into the skin to revive it overnight, making it bouncy and noticeably smoother than it was, even with her already well-rounded skincare regimen. Who It's For: Though Mollie’s skin is sensitive, she didn’t experience any irritation from this 20 percent niacinamide serum—the highest concentration of the active on this list—except when she layered it directly with her prescription retinoid. Soothing allantoin, licorice root extract, ascorbyl glucoside, and epigallocatechin gallate, the latter of which has skin-brightening and antioxidant benefits, make it an excellent choice for most sensitive skin and those aiming to improve overall skin damage, especially that induced by UV exposure. Worth Noting: Because this product contains such a high concentration of niacinamide, it may not be suited for extremely sensitive skin types or layering with other active ingredients, like retinol. Key Ingredients: Acetyl glucosamine, licorice root extract, epigallocatechin gallate | Fragrance-Free: Yes | Application: Once or twice daily | Size: 0.67 oz InStyle Mollie, tester with sensitive, combination skin: “This is the first niacinamide I've ever used that I feel truly works…this is a product I would buy on my own over and over after these results.” Best Niacinamide Serum for Dark Spots PCA SKIN Vitamin B3 Brightening Serum Credit: PCA SKIN $130 at Amazon $130 at Nordstrom $130 at Dermstore Why We Love It: The first thing our tester Danielle noticed about this formula is how quickly it absorbed—she times her morning routine down to the minute, and incorporating this serum didn’t disrupt her schedule at all, sinking into our skin to deliver hydration within 30 seconds while making a nice canvas for subsequent skin care and makeup products. Though Danielle is prone to redness, this formula didn’t exacerbate it or cause any irritation. At the end of our eight-week testing period, she was most surprised by how well this formula evened out her dark spots. Who It's For: This is ideal for someone who wants to completely even their skin tone—reduce dark spots, fade redness, and brighten a sallow appearance—without causing sensitivity. Six percent niacinamide works to soothe the skin and calm redness while a blend of extracts (green tea, mulberry, and plankton) helps brighten discoloration. Worth Noting: This serum may not be suitable for all budgets. Key Ingredients: Mulberry extract, plankton extract, glycerin | Fragrance-Free: Yes | Application: Morning and night | Size: 1 oz Danielle, tester with dry skin and severe redness: “I really like how it felt on my skin…I was pleased with the results…I can tell that the dark spots are much less visible.” Best Niacinamide Serum for Dry Skin Glow Recipe Watermelon Glow Niacinamide Dew Drops Credit: Sephora $36 at Amazon $36 at Sephora $36 at Glowrecipe.com Why We Love It: InStyle tester Arnesia loved how this product made her dry skin feel so much that she says she slicked on more than necessary. It's very cooling and smooth as you apply it, and once it absorbs, it leaves the skin feeling very soft, hydrated, and illuminated. Despite that, it never made her skin feel sticky or tacky, just comfortable and fully hydrated, so much so that she often had to hold back from touching her skin. It also provided a pretty radiance and, with regular use, made her complexion more even. Who It's For: Because of the blend of hydrating watermelon, hyaluronic acid, and moringa seed oil, this is an ideal choice for someone who has dry skin and wants more moisture without weighing down their skin. It’s also a nice pick for someone who wants instantly glowy skin, which comes courtesy of all that hydration rather than any shimmer or pearlescence. Worth Noting: This product contains 0.5 percent natural fragrance, and it didn’t irritate our tester's skin. As long as you don't mind the scent of watermelon candy as you apply your serum (Arnesia says the scent fades as the product dries), you'll likely love this product. Key Ingredients: Watermelon, hyaluronic acid, moringa seed oil | Fragrance-Free: No | Application: Once or twice daily | Size: 1.35 oz InStyle Arnesia, tester with dry skin and hyperpigmentation: “Overall, my skin looked brighter and healthier. I struggled a bit with some texture issues in my skin over the course of testing, and anytime I used this, it helped to smooth it out and make it appear much more even…and just more dewy and glowy.” Best Niacinamide Serum for Oily Skin Glossier Super Pure Serum with Niacinamide + Zinc Credit: Sephora $45 at Amazon $34 at Glossier.com Why We Love It: This featherlight formula is easy to integrate into your routine. It absorbs quickly, and while our tester Jackie didn’t think it was doing anything at first because it was so lightweight on the skin, she realized that wasn’t the case once she saw her before and after photos. She loved the brightening and clarifying effects of this serum and how it provided ample hydration, even in the winter, without overwhelming her oily skin. Her overall skin tone was improved, with less redness, and she had no breakouts throughout the entirety of the testing period. Who It's For: If you have an oily and/or acne-prone complexion, you'll find this thin formula refreshing and comfortable. The inclusion of zinc also helps tame excess oil and kill acne-causing bacteria. Those who love a high-maintenance, multistep routine will appreciate that this Glossier serum was created to be layered with a variety of skincare products and is relatively undetectable on the skin once it dries. Worth Noting: This formula is on the thinner side, so a little bit goes a long way. Key Ingredients: Glycerin, zinc, allantoin | Fragrance-Free: Yes | Application: Once or twice daily | Size: 1 oz InStyle Jackie, tester with dry skin and large pores: “It's the most lightweight, thin, and water-like product I've ever used…it still felt hydrating though. My skin looked brighter and clearer after using this product consistently, with lighter freckles/redness on my face and some slightly smoother texture on my forehead.” Best Niacinamide and Hyaluronic Acid Serum Westman Atelier Skin Activator Serum with Hyaluronic Acid + Niacinamide Credit: Westman Atelier $189 at Amazon $125 at Nordstrom $150 at Sephora Why We Love It: We were instantly drawn to this treatment by its luxe packaging—a refillable canister topped with a cooling rollerball that helped spread the serum across the face (without wasting any on our fingertips!) while depuffing, which our tester Joie appreciated each morning. She says she genuinely looked forward to using this product every day as a quick self-care ritual, but it was the results that had her coming back for more: noticeably brighter, smoother, and more hydrated skin that had an effortless glow, even in the dead of winter. Who It's For: Try this formula if you have very dry skin that’s in need of a brightening boost, or, like Joie, need to add an extra softening and hydrating step to your skincare routine when fighting sub-zero temperatures. These extra benefits come from four different forms of hyaluronic acid to deliver deep hydration to multiple layers of the skin, and ceramides, which condition and soften. Worth Noting: This product is refillable, so when it’s time to restock, be sure to keep your bottle. Key Ingredients: Ceramides, four types of hyaluronic acid, peptides, adenosine | Fragrance-Free: Yes | Application: Morning and night | Size: 0.67 oz Credit: InStyle Credit: InStyle Joie, tester with combination skin: “I was super pleased with the results after consistently using this serum. The product did more than I expected and really made a difference to my overall complexion! I could honestly see results even after the first use, and from there, it consistently helped keep my skin glowing and moisturized during the height of a Midwest winter.” Best Niacinamide Serum for Hyperpigmentation ISDIN Melaclear Advanced Credit: ISDIN $180 at Amazon $180 at Dermstore $180 at Skinstore.com Why We Love It: Quite frequently, it’s nearly impossible to fade old dark spots, especially acne scars, but this formula started fading them in four weeks. In just two weeks, the serum started smoothing out our tester’s uneven skin texture and shrinking her supersized pores. Plus, it instantly made her skin look more radiant. The gel formula absorbs quickly and layers well with other products, never pilling or clumping. Who It's For: The product includes a powerhouse blend of skin-brightening ingredients—in addition to niacinamide, it contains known dark-spot-destroyers tranexamic acid and licorice root extract, as well as exfoliating phytic and mandelic acids to slough away discoloration. This makes it a must-try for those who are struggling with all forms of hyperpigmentation. Worth Noting: This formula contains a fragrance that could sensitize reactive skin types. Key Ingredients: Tranexamic acid, licorice root extract, phytic acid, mandelic acid | Fragrance-Free: No | Application: Morning and night | Size: 1.7 oz InStyle Cara, tester with dry skin and acne scars: “I'm pleased with the results…I like that this faded my old acne scars and made my pores appear smaller….and made my skin look smoother overall.” Best Niacinamide Serum for Uneven Skin Tone Alpyn Beauty Firming Serum Credit: Sephora $58 at Amazon View on QVC $58 at Sephora Why We Love It: This silky, lightweight gel works similarly to a gentle retinol, giving the skin an instant radiance while providing a noticeable tightening effect—and it improved the firmness of our tester Chantia’s skin throughout the testing period. It smoothed the fine lines around her eyes, helping her look more revitalized and awake. Though her skin is prone to acne, this formula never irritated it and did a great job moisturizing dry patches without feeling heavy. Who It's For: This is best for someone who wants to treat the effects of aging as one of the star ingredients, rambutan, is considered a retinol alternative (just like bakuchiol) and helps smooth and brighten the skin (as does niacinamide, of course). It’s also one to consider if you’re passionate about sustainability. It's packaged in a fully recyclable component and serum features sustainably harvested plant extracts. Worth Noting: This formula may not be suitable for sensitive skin types due to its retinol-like properties. Key Ingredients: Nettle extract, rambutan extract, squalane | Fragrance-Free: Yes | Application: Once or twice daily | Size: 1 oz Chantia, tester with combination skin and acne scars: “The serum did an excellent job in improving the texture of my skin [and] I am very pleased with how vibrant my skin looks now…my friends also weren't telling me I look tired and sleepy as much as they used to.” Best Niacinamide Serum for Sensitive Skin Dr. Barbara Sturm Niacinamide Serum Credit: Sephora $160 at Amazon $160 at Sephora $160 at Goop.com Why We Love It: Our tester Kaitlin often refers to herself as an “acne survivor,” having completed three rounds of Accutane to clarify her skin. Though she was wary of testing a new product for fear of a negative reaction, her skin adored this serum. For the first 10 days of testing, she noticed no change to her skin, but on the eleventh day, she woke up to dramatically better-looking skin—the best it had ever looked. "My pores looked smaller, and my face looked brighter and glowier," she says. This glow also came without added oiliness, which is often her issue with products that offer a dewy or glowy finish. Who It's For: This is best for someone who has sensitive, reactive skin like Kaitlin; while niacinamide has soothing properties, other actives in the serum, including ectoin, purslane, marine plankton extracts, and fellow B vitamin panthenol, do too. Worth Noting: This product is on the pricier side. That said, Kaitlin loved how this formula made her skin look so much that she’d give up her lattes and avocado toast forever to afford this if she had to. Key Ingredients: Marine plankton extract, purslane extract, ectoin, panthenol | Fragrance-Free: No | Application: Morning and night | Size: 1 oz Kaitlin, tester with combination, formerly acne-prone skin: "My skin is deeply sensitive, and it shows its displeasure by making my face bright red that lasts for hours. This didn't happen one bit with the serum. I just patted it on, and then 10 days later, it looked its best ever." Best Niacinamide Serum for Redness Typology 12% Niacinamide Serum Credit: Typology $51 at Typology.com View on Typology.com Why We Love It: This serum is very simple (just 10 ingredients!), but it delivers serious results. Before trying it, our tester Taylor’s biggest gripes about her skin were its inconsistent tone, most notably her redness, and this formula dramatically evened everything out, calming redness and fading dark spots. Though it contains a high concentration of niacinamide, she experienced zero irritation while testing this product (and a little of it went quite a long way). Who It's For: This product is ideal for someone who wants a fuss-free and effective formula to even out their skin tone. Its only active is the 12 percent niacinamide, but because the ingredient is such a powerhouse, you’ll see a transformation in your skin. The glass packaging is also recyclable. Worth Noting: Our tester found this product to be a bit sticky upon application. Key Ingredients: Niacinamide|Fragrance-Free: No|Application: Morning and night|Size: 1 oz Taylor, tester with combination skin and discoloration: “Looking back at the before photos, I was shocked at how much the color in my face evened out. My skin is less red, and my sun spots have faded…I noticed a slight change in the fine lines around my eyes…my skin just looks more even overall.” Best Niacinamide Serum for Glowing Skin Drunk Elephant B-Goldi Bright Drops Credit: Drunk Elephant $39 at Amazon $39 at Ulta $39 at Sephora Why We Love It: We were admittedly skeptical of this product after initially seeing the golden pearlescence of the formula (it looks more like a highlighter than a serum), but our tester fell in love with its instant and lasting effects. Just a pea-sized amount was enough to cover her entire face and add a radiant (not sparkly) glow. Throughout the testing period, she observed her skin getting brighter and smoother, with fewer hormonal breakouts and reduced discoloration left behind by any errant pimples. Who It's For: This is absolutely for someone who wants something of a makeup-skin care hybrid, as the formula adds a golden glow to the skin. But if you’re looking to use it as a makeup alternative, that works, too—the nourishing properties provided by the squalane and jojoba oil make it a great substitute for a tinted moisturizer. It’s also worth trying if you don’t want to take any products out of your existing regimen, as it’s meant to be mixed with your favorite serums, creams, or oils. Worth Noting: This serum leaves a glowy, makeup-like sheen that most will consider better suited for daytime use. Key Ingredients: Diglucosyl gallic acid, squalane, mulberry leaf extract | Fragrance-Free: Yes | Application: Once or twice daily | Size: 1 oz InStyle Alexa, tester with combination skin and large pores: “I am very happy with the results! The product looked very cosmetic to me when first using it—I thought it would have no effect on my skin, but in the end, it helped even more problems than it advertises.” Our Testing Process We extensively researched what niacinamide serum formulas best combat large pores, texture, and inflammation, and made a list of 29 niacinamide serums that aim to brighten and improve skin texture. We then sent the products to a diverse group of testers with varying skin types. They incorporated the serums into their daily routines for eight weeks to see how they performed against a variety of skin concerns, while taking the skin’s overall condition and appearance into account. Our testers recorded immediate and ongoing results to see if the serum provided any long-term benefits to the skin. Their insights were then used to narrow the list to these 15 top-performing niacinamide serums. What to Keep in Mind Skin Concern: With consistent use of a good niacinamide serum, you should see clearer, smoother, brighter, and more youthful-looking skin that stays hydrated longer, is less prone to irritation, and has less noticeable pores. While you may have some specific concerns in mind that you’d like to address, it never hurts to see a dermatologist, who can weigh in on how best to achieve your skin goals. “If you don't have any specific concerns, then a hydrating serum would be a nice place to start,” says board-certified dermatologist Hadley King, M.D. Supporting Ingredients: Generally speaking, Dr. King says niacinamide plays well with most other ingredients, making it an easy addition to any skin care routine. Victoria Fu, cosmetic chemist and cofounder of the Chemist Confessions podcast, says the ingredient “has been tested in combination with many of the major skin care actives such as retinol, alpha-hydroxy acids (AHAs), and vitamin C, and found to be safe and effective.” All of our experts suggest looking for humectants like glycerin, hyaluronic acid, and polyglutamic acid, as well as ceramides and panthenol, if you’re hoping to help support your skin barrier. Look for the best-supporting ingredients and the benefits they provide below that align with your skin care goals. Formula Texture: Niacinamide can be found in anything from creams to gels and water-based formulas. “Lightweight, watery or gel-like formulas may be better for oily and acne-prone skin as they absorb quickly without adding excess oil,” says Dr. Murphy-Rose. Meanwhile, “thicker and more opaque formulations tend to have more emollients in them,” Dr. King says. “Emollients support the skin barrier and are helpful for any skin type, and particularly important for drier and sensitive skin types.” Your Questions, Answered How to use niacinamide serum? According to Fu, niacinamide serums tend to be water-based, with a lightweight, slightly thicker-than-water feel, so they should be applied as the first step of your skin care routine after washing your face (and toning, if you partake). Layering your products in order from lightest to heaviest will ensure proper absorption of all your actives; if you put a water-based serum on top of an oil, it won’t be able to get through. “Apply a few drops to the face and neck, and gently pat it into the skin until fully absorbed, then apply the next steps in your routine,” says Dr. Murphy-Rose. What is the best niacinamide serum? After extensive research and testing, Sunday Riley B3 Nice 10% Niacinamide Serum is our top pick. It absorbs easily and contains antioxidants that brighten and clear skin while preventing dark spots from forming. It contains potent antioxidants, resveratrol and EGCG, to protect the skin from free radicals, which can contribute to dark spot formation. It also contains Brightenyl, an ingredient that prevents dark spots from forming, reduces redness, and shrinks pores. Does niacinamide reduce redness? Yes, one of niacinamide’s main benefits is reducing redness and other inflammation. Formulas containing ceramides and licorice root, green tea, or chamomile extracts will be especially helpful in this, as they are also known to reduce redness. What percentage of niacinamide should I use? Serums on our list have niacinamide concentrations all the way up to 20 percent, but Victoria Fu, a cosmetic chemist, says that more isn’t always better. “There isn’t any testing that shows using niacinamide at higher concentrations would provide additional benefits,” she says. Instead, she suggests formulas with concentrations between two and five percent. For super sensitive or rosacea-prone skin, Dr. Murphy-Rose recommends taking precaution even further with a warning to stay below three percent. “I can tell you anecdotally that five percent is too high for many,” she says. “Using a serum with too much niacinamide can lead to skin irritation, redness, and a temporary burning sensation.”However, Fu says chemists love formulating new skin care with niacinamide because it’s so easy to pair with other actives and it’s generally well tolerated by most skin types. On the flip side, niacinamide is included in a surprising amount of products, meaning that you could be—albeit unknowingly—layering way too much onto skin. “If you develop a sudden case of irritation without changing up your routine all that much, definitely give all your products' ingredient lists a quick scan to see if you're unknowingly layering five or more different products made with niacinamide,” she says. If you’re overdoing it, simplify your routine and keep the strongest concentrations to every other day. What is niacinamide serum good for? “It can help with oil regulation, barrier function, aging, hyperpigmentation, acne, and eczema,” says Dr. King. She added that it's great for improving both tone and texture in addition to reducing redness and protecting the skin from free radicals. When should I use niacinamide serum? “Niacinamide is not known to cause any sort of photosensitivity, so you can use it both day and night,” says Fu. It’s also not light-sensitive, meaning the ingredient won’t be rendered inactive if it’s exposed to UV. Just remember that if you’re applying your niacinamide serum in the morning, don’t forget to finish your routine with sunscreen—you don’t want to undo all your hard work combating sun damage. Is it okay to use niacinamide serum every day? “It does not tend to cause irritation or inflammation, and results will be improved with regular use,” Dr. King says of the ingredient, so long as you’re using the right concentration. Start low and work your way up; most people won’t need a formula that features a concentration above five percent. What other actives can I pair with niacinamide? In theory, you can use any of your go-to active ingredients with niacinamide. However, it’s worth noting that niacinamide is most stable in a higher pH formula, says Dr Murphy-Rose, so it may not be the best match for ingredients that tend to be formulated into products at a more acidic pH, like vitamin C. “While not harmful, ascorbic acid and niacinamide may become less effective if combined in the same product,” she explains. If you’re unsure, consider applying your vitamin C serum in the morning and your niacinamide serum at night. “I particularly like to use it at night with a retinoid, because it can help counteract the dryness and irritation that retinoids often cause,” she says. Why Shop With Us Emily Orofino is a beauty writer, editor, and consultant with nearly 15 years of experience in the industry. She was long skeptical of niacinamide until she read a great deal of the research on the ingredient while working for a dermatologist. For this story, she spoke with experts to break down exactly what makes up a solid niacinamide serum. Emma Greene is a fashion and beauty writer at InStyle who is passionate about skin care and uses a niacinamide serum every day. She updated this article with new testing and the most up-to-date information. If she had to pick a favorite, she's partial to The Ordinary's niacinamide serum. The following experts spoke with InStyle for this story: Dr. Blair Murphy-Rose is a board-certified dermatologist and founder of Skincare Junkie.Dr. Hadley King is a board-certified dermatologist specializing in medical and cosmetic dermatology.Victoria Fu is a cosmetic chemist and cofounder of the Chemist Confessions podcast. Sources InStyle uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc therapy in dermatology: a review. Dermatol Res Pract. 2014;2014:709152. Bissett DL, Robinson LR, Raleigh PS, et al. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007;6(1):20-26. Read more: Shopping