Colourized microscopy image of the protist Tritrichomonas foetus

True cyst formation underlies persistence and drug tolerance in Tritrichomonas foetus

The protist Tritrichomonas foetus can cause disease in cows and cats. Lucrecia Iriarte et al. show that, under stress, the parasite forms cysts that reduce drug susceptibility.

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    This Nature Conference, held in Nanjing in October 2025, explores how the integration of AI with biological sciences unlocks immense potential for groundbreaking discoveries. It will cover multi-modal data mining, protein engineering, molecular and cellular engineering, large language models, foundation models for understanding complex biological systems and diseases, and the emergence of life.

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Latest Research articles

  • Supercurrents flowing through thin superconducting nanowires can be quenched by applying a gate voltage, an effect known as gate-controlled suppression of superconductivity. Here, using a scanning nitrogen-vacancy magnetometer at sub-Kelvin temperatures, the authors report that this phenomenon also manifests in a suppression of Meissner screening and is thus not restricted to transport.

    • K. J. Knapp
    • U. Ognjanović
    • C. L. Degen
    ArticleOpen Access
  • The experimental realization of how temporally correlated noise influences growth universality classes remained unconfirmed. Authors demonstrate a direct crossover from the Villain- Lai-Das Sarma (VLDS) to the temporally correlated noise-driven KPZ (TCN-KPZ) universality class and identify adatom escape as the microscopic origin of the correlated noise, establishing a direct link between atomistic kinetics to macroscopic morphological evolution.

    • Mrinal Manna
    • Sourav Mukherjee
    • Rajib Batabyal
    ArticleOpen Access
  • Single-atom catalysts offer high efficiency but face aggregation and degradation at elevated temperatures. Here, the authors introduce a thermally stable high-valent iridium single-atom catalyst to enhance CO2 electrolysis in solid oxide electrolysis cells.

    • Shaowei Zhang
    • Shuo Wang
    • Xinhe Bao
    ArticleOpen Access
  • Inspired by densely packed sclereids with interconnected pit structures in Raphia hookeri seed, authors fabricate bioinspired structural materials with weak anisotropy and high toughness.

    • Jiajun Mao
    • Jia Yan
    • Qunfeng Cheng
    ArticleOpen Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

  • Multiplexed biosensing is often limited by crosstalk between sensors. Here, authors distribute sensing across microbial communities and use timer-resolved modelling and machine learning to infer multiple chemical concentrations from cross-reactive and indirect responses.

    • Katherine E. Duncker
    • Ashwini R. Shende
    • Lingchong You
    ArticleOpen Access
  • Chemotherapy is reported to induce cancer-cell senescence, which shapes tumor treatment response. Here, the authors show that chemotherapeutic gemcitabine-induced senescence leads to a stiffened stroma, triggering Piezo1-NRF2 signaling in cancer cells and promoting ferroptosis resistance.

    • Xinxin Liu
    • Zhihua Huang
    • Yinmo Yang
    ArticleOpen Access
  • Animals have moved from water to land many times, but whether they used the same genetic routes has remained unclear. This study shows that independent land transitions relied mostly on ancient, conserved genes, with lineage-specific changes converging on similar stress-related functions.

    • Gemma I. Martínez-Redondo
    • Klara Eleftheriadi
    • Rosa Fernández
    ArticleOpen Access
  • Understanding immune correlates of SARS-CoV-2 infection risk in children, especially those with hybrid immunity, remains underexplored. Here, the authors conduct a cohort study revealing that higher nucleocapsid-binding and Omicron-specific neutralizing antibodies significantly reduce infection risk, suggesting these markers could guide tailored vaccination strategies and risk assessments in pediatric populations.

    • Katherine L. Hoffman
    • Grace Marshall
    • Marco Carone
    ArticleOpen Access
  • Cryo-EM maps often contain uneven signal, with strong structural features alongside weak but biologically important context. Here, authors present LocScale-2.0, which co-visualises high -resolution and contextual features while providing confidence scores f or interpretation.

    • Alok Bharadwaj
    • Reinier de Bruin
    • Arjen J. Jakobi
    ArticleOpen Access

Subjects within Biological sciences

Subjects within Health sciences

  • The global map of riverfront landscapes reveals that nearly one-fifth of riverfronts have been modified by human activity. This extensive footprint creates widespread fragmentation that fundamentally reshapes land-water interactions, providing crucial insights for rethinking global river management.

    • Fanxuan Zeng
    • Chunqiao Song
    • Tamlin M. Pavelsky
    ArticleOpen Access
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    Despite a low share of gas-fired generation, French electricity prices showed stronger relative increases during the energy crisis. In the present paper, authors demonstrate how nuclear unavailability led to higher French import dependence, and evaluate the impact of the Spanish gas cap.

    • Sarah Schreyer
    • Anton Tausendfreund
    • Dirk Witthaut
    ArticleOpen Access
  • Here, the authors propose structured operator learning with spectral decomposition, sparse regression, and cross-view regularization to recover stable, interpretable governing equations under noisy, high-dimensional, and distribution-shifted data.

    • Dongni Jia
    • Shuai Li
    • Xiaofeng Zhou
    ArticleOpen Access
  • Navigation services concentrate traffic onto a few roads as adoption increases. Simulations in Florence, Milan, and Rome show route diversity drops by up to 14% at full adoption, and CO2 benefits vanish or reverse beyond a city- and service-specific threshold.

    • Giuliano Cornacchia
    • Mirco Nanni
    • Luca Pappalardo
    ArticleOpen Access

Subjects within Scientific community and society

  • Japan deserves more attention than it has so far received in Western narratives about the expansion of humans across Asia. It has over 10,000 Palaeolithic sites, many of which are well-dated. Japan provides excellent examples of Pleistocene sea-faring and long-distance Palaeolithic exchange networks. Okinawa in the Ryukyu Islands may provide one of the earliest examples of humans deliberately trans-locating an animal to a new environment. Japan may also have been a starting point for the colonisation of the Americas.

    • Robin Dennell
    CommentOpen Access
  • Image

    Hybrid modelling using machine learning can help improve the robustness and comprehensiveness of economic impact assessments of climate change by combining data with theory, bridging silos across social, economic, and financial systems, and linking micro- and macroeconomic scales.

    • Anton Orlov
    • Jana Sillmann
    CommentOpen Access
  • Image

    Online behavioural research faces a growing methodological and epistemic threat as participants increasingly rely on large language models: LLM Pollution. Amid accumulating empirical evidence of contamination, we introduce a conceptual framework that distinguishes three variants — Partial LLM Mediation, Full LLM Delegation, and LLM Spillover. Their interaction distorts samples, biases inferences, and fuels an escalating methodological arms race. We outline mitigation strategies spanning researcher practices, platform accountability, and community adaptation.

    • Raluca Rilla
    • Tobias Werner
    • Anne-Marie Nussberger
    CommentOpen Access
  • Image

    Genomic data could transform healthcare, but African populations are underrepresented, currently limiting benefits. Here the authors highlight how addressing political, financial, and social barriers and advancing equitable national genome projects is essential.

    • Mohamed Zahir Alimohamed
    • Ghada El-Kamah
    • Michele Ramsay
    CommentOpen Access
  • Image

    This comment introduces four governance actions that consider how sustainability, evaluation, safety, and cooperation can be integrated into the transformation of open-source AI, thereby reducing uncertainties and challenges posed by open-source AI for sustainable global prosperity.

    • Min Chen
    • Kai Wu
    • Guonian Lü
    CommentOpen Access
  • Image

    Consortia of microbial isolates, also known as synthetic communities (SynComs), are increasingly used to study and harness microbe-microbe and microbe-host interactions. Since “synthetic” potentially evokes negative connotations, we propose adopting the term “Defined Microbial Community” for practical applications.

    • Hanna Koch
    • Thomas Clavel
    • Angela Sessitsch
    CommentOpen Access
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Materials science and chemistry

Here, we provide a snapshot of exciting work published in materials science and chemistry. From new forms of matter to well-known materials, topics include oxides, 2D materials, nanomaterials, ceramics, metamaterials, polymers, biomaterials, organic and inorganic functional materials, etc.
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