This supplement has its origins on May 15, 2003, when the National Human Genome Center at Howard University held a small but important workshop in Washington DC. The workshop, Human Genome Variation and 'Race', and this special issue of Nature Genetics were proposed by scientists at Howard University and financially supported by the Genome Programs of the US Department of Energy, through its Office of Science; the Irving Harris Foundation; the National Institutes of Health, through the National Human Genome Research Institute; and Howard University. As summarized by Francis Collins, director of the National Human Genome Research Institute, the workshop focused on several key questions: “What does the current body of scientific information say about the connections among race, ethnicity, genetics and health? What remains unknown? What additional research is needed? How can this information be applied to benefit human health? How might this information be applied in nonmedical settings? How can we adopt policies that will achieve beneficial societal outcomes?” This supplement, supported by the Department of Energy through a grant to Howard University, contains articles based on the presentations at this workshop.
With very rare exceptions, all of us in the US are immigrants. We bring with us a subset of genes from our homelands, and for many Americans, often first-generation but more commonly second-generation, the plural noun 'homelands' is appropriate. From this perspective, the most immediately obvious characteristic of 'race' is that describing most of us as Caucasian, Asian or African is far too simple. Despite attempts by the US Census Bureau to expand its definitions, the term 'race' does not describe most of us with the subtlety and complexity required to capture and appreciate our genetic diversity. Unfortunately, this oversimplification has had many tragic effects. Therefore, we need to start with the science, which is what the Howard University conference did. To quote further from Francis Collins' excellent commentary, “As a historically black university, Howard University served science and society by sponsoring this frank discussion, and the National Human Genome Center's leaders are to be congratulated for their vision in putting together such a thought-provoking agenda...”. I completely agree.
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