Robust antibody responses in 70–80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021

Subbarao, Sathyavani; Warrener, Lenesha; Höschler, Katja; Perry, Keith R.; Shute, Justin; Whitaker, Heather; O’Brien, Michelle; Baawuah, Frances; Moss, Paul; Parry, Helen; Ladhani, Shamez; Ramsay, Mary; Brown, Kevin; Amirthalingam, Gayatri

doi:10.2807/1560-7917.es.2021.26.12.2100329

Eurosurveillance

2021

DOI: 10.2807/1560-7917.es.2021.26.12.2100329

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Robust antibody responses in 70–80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021

Sathyavani Subbarao

¹

,

Lenesha Warrener

²

,

Katja Höschler

³

et al.

Abstract: Sera were collected from 185 adults aged ≥ 70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in > 94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom’s approach of prioritising the first dose and delaying the… Show more

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Cited by 45 publications

(42 citation statements)

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“…This agrees with recent data published by Terpos et al [22], who also found that the anti-Spike-RBD IgGs response was more sustained in female than in male octogenarians after vaccination with Pfizer BNT162b2 mRNA vaccine. In keeping with previous reports [23][24][25][26], we also observed a gradual reduction of total anti-SARS-CoV-2 RBD antibodies level in older individuals (i.e., aged 60 years or older). In particular, a significant difference by age (≤60 years vs. >60 years) could be noted after the first mRNA vaccine dose (~1.3-fold), which was magnified after the second dose (~1.9-fold).…”

Section: Discussionsupporting

confidence: 92%

Anti-SARS-CoV-2 Receptor-Binding Domain Total Antibodies Response in Seropositive and Seronegative Healthcare Workers Undergoing COVID-19 mRNA BNT162b2 Vaccination

Salvagno

¹

,

Henry

²

,

Piazza

³

et al. 2021

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…This agrees with recent data published by Terpos et al [22], who also found that the anti-Spike-RBD IgGs response was more sustained in female than in male octogenarians after vaccination with Pfizer BNT162b2 mRNA vaccine. In keeping with previous reports [23][24][25][26], we also observed a gradual reduction of total anti-SARS-CoV-2 RBD antibodies level in older individuals (i.e., aged 60 years or older). In particular, a significant difference by age (≤60 years vs. >60 years) could be noted after the first mRNA vaccine dose (~1.3-fold), which was magnified after the second dose (~1.9-fold).…”

Section: Discussionsupporting

confidence: 92%

Anti-SARS-CoV-2 Receptor-Binding Domain Total Antibodies Response in Seropositive and Seronegative Healthcare Workers Undergoing COVID-19 mRNA BNT162b2 Vaccination

Salvagno

¹

,

Henry

²

,

Piazza

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Although the evidence on single-dose immunogenicity of BNT162b2 in older adults is mixed, [28][29][30] pooled data from four ChAdOx1 trials, including over 950 participants aged 70 years and older, indicated vaccine effectiveness of 63•9% (95% CI 46-75•9) against all infection at 22-90 days after a single dose, 17 which is in line with our findings. Our estimates of vaccine effectiveness against all infection are not dissimilar to those from phase 3 efficacy testing of the single-dose Ad26.COV2.S vaccine (Janssen), which was 67•9% (95% CI 38•2-82•8) effective against symptomatic COVID-19 at 28 days or more after vaccination in those aged 60 years and older.…”

Section: Chadox1 Bnt162b2supporting

confidence: 88%

Vaccine effectiveness of the first dose of ChAdOx1 nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of long-term care facilities in England (VIVALDI): a prospective cohort study

Shrotri

¹

,

Krutikov

²

,

Palmer

³

et al. 2021

The Lancet Infectious Diseases

Self Cite

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Overall, older men had a nearly 50% lower anti-SARS-CoV-2 RBD total antibody response compared to young women [11]. Similar evidence was garnered in other studies, whereby lower vaccine immunogenicity was also reported in older people and/or in males [17][18][19][20][21]. Given the increased risk for poor COVID-19 progression and outcomes associated with advanced age and male sex, these groups may be especially vulnerable in the setting of a diminished immune response [22].…”

Section: Why?supporting

confidence: 63%

Anti-SARS-CoV-2 Antibodies Testing in Recipients of COVID-19 Vaccination: Why, When, and How?

Lippi

¹

,

Henry

²

,

Plebani

³

2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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