The explosion of single-cell and systems approaches in immunology risks leaving the uninitiated behind. Bonaguro et al provide a guide to #Systems_immunology that is designed for immunologists who want an introduction to the area. DOI:10.1038/s41590-022-01309-9
Epithelial cells use an immune-like mechanism to extrude and kill neighboring precancerous cells. Maruyama and colleagues demonstrate that LILRB3 on normal epithelial cells recognizes elevated Class I on transformed cells and triggers the extrusion process.
In this resource Streets and colleagues provide a timeline of CD4+ and CD8+ T cell lineage commitment, identifying sequential waves of TCR signaling that initiate CD4+ T cell then CD8+ T cells lineage differentiation. Read it here: rdcu.be/djHe5nature.com/articles/s4159…
A multiomic atlas of T cell exhaustion in chronic viral infection reveals molecular programs of exhausted T cell subsets, divergent clonal exhausted T cell differentiation trajectories and suggests TCR signal strength as a driver of clonal fate rdcu.be/cZDQL
Haas and colleagues use single cell multi-omics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information.
rdcu.be/cBOP1
SARS-CoV-2 infection is milder in children. Dowell et al. show that immune responses are higher in children, retained for 12 months or longer and can neutralize Alpha, Beta and Delta variants. rdcu.be/cDH9v & see the Research Briefing rdcu.be/cDIcR
Helper T cell subsets are characterized functionally by the cytokines they produce. Benoist and colleagues demonstrate that in vivo helper T cells do not manifest as discrete helper subsets but rather form a continuum shaped by microbial exposure rdcu.be/cd8to
Dubrot et al use genome-scale in vivo CRISPR screens to look at #immune_evasion mechanisms across #cancer models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape. rdcu.be/cWc9T
Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here: rdcu.be/dLY2onature.com/articles/s4159…
Blacher et al find aging disrupts the myeloid circadian clock and identify KLF4 as a critical oscillating transcription factor that regulates macrophage gene expression and phagocytosis. rdcu.be/cEf5m@EranBlacher@StanfordMed
New review: The transcription factor TCF-1 has multiple roles during T cell development and in mature T cells. Gounari and Khazaie review the potential mechanisms by which TCF-1 regulates gene expression rdcu.be/cNvlc
