Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
AI Chatbot
Meet the React-to-Me AI Chatbot! Designed to answer your questions about Reactome Pathways.
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
[May 21, 2026] In their February 2026 Nature Genetics paper "Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants", Geller et al. describe the results of a genome-wide association study (GWAS) of a northern European population that identified 13 genome-wide significant loci correlated with susceptibility to infection with the Omicron strains of SARS-CoV-2. Gene set enrichment analysis showed these 13 loci are overrepresented in Reactome pathways for protein glycosylation, suggesting plausible mechanisms for the enhanced infectivity of Omicron variant SARS-CoV-2 viruses.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by a grant from the US National Institutes of Health (U24 HG012198).
Version 97 released on June 25, 2026
Human Pathways
Reactions
Proteins
Small Molecules
Drugs
Literature References
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