Pinned
Our lab website is finally online! pacesalab.com
You can find information about our research, publications, and on-going developments in the lab.
Martin Pacesa
2,458 posts
Martin Pacesa
@MartinPacesa
Assistant Professor at the University of Zurich. 🖥️ protein design, machine learning🤖, crystallography💎, cryoEM🔬. Avid weirdness connoisseur 🎩
- Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
00:00 - Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6 nature.com/articles/s4158…
00:00 - OMG, WE'VE BEEN WAITING FOR YEARS AND IT'S HERE! THE NEW CRISPR CLASSIFICATION IS HEREEEE!!! 🔥🔥🔥 pubs.acs.org/doi/10.1021/ac…
- Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators. nature.com/articles/s4158…
00:00 - I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
- I’m so happy to announce that the results of our study on the mechanistic basis of Cas9 off-target activity have been published in Cell! cell.com/cell/fulltext/…
- AlphaFold/ColabFold no longer dominating at this year’s CASP15 😮
- Very excited to see our work on Cas9 conformational activation out in @Nature ! nature.com/articles/s4158… What started as a very poor crystal structure back in 2017 in the @MartinJinek lab, turned into a full blown cryoEM project during the pandemic.
- THEY SAID WE COULDN'T DO IT........well, no one actually said that. But in our updated manuscript with @CasperGoverde, @GoldbachNico, and @befcorreia we show you can now design soluble analogues of membrane proteins with preserved functional features! biorxiv.org/content/10.110…
- Just before the New Year: BindCraft v1.5! Please fill out this form to request new features and help us make BindCraft even better. forms.gle/XsGHDCyHtczVba…
00:00 - v1.2.0 of BindCraft released on github. Includes improvements to the Colab notebook, new design protocol options, several critical bug fixes in the run script, QoL improvements, and streamlining of the installation script.Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…00:00
