GPR176

GPR176
Identifiers
Aliases	GPR176, HB-954, G protein-coupled receptor 176
External IDs	OMIM: 612183; MGI: 2685858; HomoloGene: 5226; GeneCards: GPR176; OMA:GPR176 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	39,920,266 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,203,900 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ascending aorta; ; saphenous vein; ; right coronary artery; ; Descending thoracic aorta; ; pons; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gonad; ; tibial arteries;
	Top expressed in
	calvaria; ; stroma of bone marrow; ; suprachiasmatic nucleus; ; substantia nigra; ; arcuate nucleus; ; supraoptic nucleus; ; subiculum; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway; circadian behavior; rhythmic process; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11245
	381413
	ENSG00000166073
	ENSMUSG00000040133
	Q14439
	Q80WT4
	NM_001271854; NM_001271855; NM_007223
	NM_201367
	NP_001258783; NP_001258784; NP_009154
	NP_958755
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 176 is a protein that in humans is encoded by the GPR176 gene.^[5]^[6]

It is expressed by neurons in the suprachiasmatic nucleus, where it negatively regulates cAMP production in an apparently agonist-independent fashion. Its expression increases at night, indicating it may be involved in circadian rhythm within the brain. Rather than interacting with the canonical G_i protein, it interacts with G_z.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166073 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040133 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hata S, Emi Y, Iyanagi T, Osumi T (April 1995). "cDNA cloning of a putative G protein-coupled receptor from brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261 (1): 121–125. doi:10.1016/0167-4781(95)00002-x. PMID 7893747.
↑ "Entrez Gene: GPR176 G protein-coupled receptor 176".
↑ Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, et al. (February 2016). "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour". Nature Communications. 7 (1) 10583. doi:10.1038/ncomms10583. PMC 4757782. PMID 26882873.
↑ Nakagawa S, Nguyen Pham KT, Shao X, Doi M (July 2020). "Time-Restricted G-Protein Signaling Pathways via GPR176, G_z, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus". International Journal of Molecular Sciences. 21 (14): 5055. doi:10.3390/ijms21145055. PMC 7404074. PMID 32709014.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166073 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040133 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hata_1995-5] Hata S, Emi Y, Iyanagi T, Osumi T (April 1995). "cDNA cloning of a putative G protein-coupled receptor from brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261 (1): 121–125. doi:10.1016/0167-4781(95)00002-x. PMID 7893747.

[entrez-6] "Entrez Gene: GPR176 G protein-coupled receptor 176".

[Nature_Communications-7] Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, et al. (February 2016). "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour". Nature Communications. 7 (1) 10583. doi:10.1038/ncomms10583. PMC 4757782. PMID 26882873.

[8] Nakagawa S, Nguyen Pham KT, Shao X, Doi M (July 2020). "Time-Restricted G-Protein Signaling Pathways via GPR176, G_z, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus". International Journal of Molecular Sciences. 21 (14): 5055. doi:10.3390/ijms21145055. PMC 7404074. PMID 32709014.

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